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Substance

Phase I - Enzymes (inactivate substrate, activate prodrug)

Phase II - Conjugation Enzymes (make substrate water-soluble)

Phase III - Drug Transport Proteins (affect absorption & excretion)

MAO

Oxydation by Cytochrome P-450 (CYP)

Oxydation by flavin-containing monooxygenase (FMO)

Reduction Enzyme

Glucuronidation by UDP-Glucuronosyltransferase (UGT)

Acetylation

Conjugation

Efflux-Transporter

Solute-Carrier Transporter (SLCT) = Influx & Efflux transporter

MAO-A

1A2

2A6

2B6

2C8

2C9

3A5

2C19

2D6

2E1

3A4

FMO

DPD

VKORC1

1A1

1A3

1A4

1A6

1A9

2B4

2B7

2B10

2B15

2B17

NAT2

TPMT

ABCG2 (BCRP)

ABCB1 (Pgp,MDR)

OAT1

OAT3

OCT2

MATE1

MATE-2K

OATP1B3

SLCO1B1 (OATP1B1)

Abiraterone

INH

Acenocoumarol

SUB

Acetaminophen (Paracetamol)

PRO

SUB

Acyclovir

INH

Adefovir

SUB

Agomelatine

SUB

Alfentanil

SUB

Allopurinol

INH

Alosetron

SUB

Alprazolam

SUB

Alprenolol

SUB

Amiodarone

INH

PRO

INH

Amitriptyline

SUB

PRO

SUB

Amlodipine

INH

SUB

Amodiaquine

SUB

Apixaban

SUB

Aprepitant

IND

INH

SUB

Aripiprazole

SUB

Armodafinil

IND

Artemether

SUB

Artemisinin

IND

SUB

IND

Astemizole

SUB

INH

Asunaprevir

SUB

Atazanavir

INH

SUB

INH

SUB

INH

SUB

INH

Atomoxetine

SUB

Atorvastatin

SUB

INH

SUB

Avanafil

SUB

Beta-Naphthoflavone

IND

Bilirubin

SUB

IND

Bisoprolol

SUB

Boceprevir

INH

SUB

INH

SUB

Bortezomib

SUB

INH

SUB

Bosentan

IND

SUB

IND

SUB

IND

SUB

Broccoli

IND

Bromocriptine

INH

SUB

IND

INH

SUB

Brussel Sprouts

IND

Budesonide

IND

SUB

IND

Bufuralol

SUB

Buprenorphine

SUB

Bupropion

SUB

INH

Buspirone

SUB

Caffeine

SUB

INH

Cannabidiol

INH

SUB

INH

SUB

INH

Carbamazepine

IND

SUB

IND

SUB

IND

PRO

INH

IND

Carisoprodol

SUB

Carvedilol

SUB

PRO

INH

SUB

Cefaclor

SUB

Ceftizoxime

SUB

Celecoxib

SUB

INH

SUB

Celiprolol

IND

SUB

Cerivastatin

SUB

Char-Grilled Meat

IND

Chloramphenicol

INH

SUB

Chloroquine

SUB

INH

SUB

Chlorpheniramine

INH

SUB

Chlorpromazine

INH

SUB

INH

SUB

Chlorzoxazone

SUB

INH

Ciclosporin (Cyclosporine)

INH

SUB

INH

SUB

INH

Cilostazol

INH

SUB

Cimetidine

INH

SUB

Cinacalcet

INH

Ciprofibrate

SUB

Ciprofloxacin

INH

Cisapride

SUB

Citalopram

SUB

INH

SUB

Clarithromycin

INH

SUB

INH

Clemastine

INH

Clobazam

SUB

INH

SUB

Clomipramine

SUB

INH

SUB

PRO

Clonazepam

SUB

Clonidine

SUB

Clopidogrel

PRO

INH

PRO

INH

PRO

SUB

INH

Clotrimazole

INH

IND

Clozapine

SUB

INH

SUB

Cobicistat

INH

SUB

INH

SUB

INH

Cocaine

INH

SUB

Codeine

PRO

SUB

Colchicine

SUB

Conivaptan

INH

SUB

Cortisol

SUB

INH

SUB

Crizotinib

INH

Curcumin

INH

IND

INH

SUB

INH

Cyclobenzaprine

SUB

Cyclophosphamide

PRO

SUB

IND

Dabigatran

SUB

Daclatasvir

SUB

INH

SUB

Danoprevir

INH

SUB

Dapsone

SUB

Darifenacin

SUB

Darunavir

INH

SUB

Dasabuvir

SUB

INH

SUB

INH

SUB

Dasatinib

INH

SUB

Debrisoquine

SUB

Deferasirox

INH

Delavirdine

INH

SUB

INH

SUB

Desipramine

SUB

Desogestrel

SUB

INH

SUB

INH

Desvenlafaxine (active metabolite of venlafaxine)

INH

IND

Dexamethasone

IND

SUB

IND

SUB

Tenofovir

INH

SUB

Dexfenfluramine

SUB

Dextromethorphan

SUB

Diazepam

SUB

Diclofenac

SUB

IND

Dienogest

SUB

Diethyldithiocarbamate

INH

Rivaroxaban

SUB

Dihydralazine

INH

Dihydrocodeine

PRO

SUB

Dihydroergotamine

SUB

Diltiazem

SUB

INH

SUB

INH

SUB

Dimethylformamide

SUB

IND

Diosmin

INH

Diphenhydramine

SUB

INH

SUB

Dipyridamole

INH

Disulfiram

INH

Docetaxel

SUB

IND

SUB

Dofetilide

SUB

Dolutegravir

SUB

INH

Domperidone

SUB

Donepezil

SUB

Doxepin

SUB

INH

SUB

Doxorubicin (Adriamycin®)

INH

SUB

Doxycycline

INH

IND

SUB

Dronedarone

INH

SUB

INH

SUB

Duloxetine

SUB

INH

SUB

INH

Dutasteride

SUB

Ebastine

SUB

Ecstasy (Mdma)

SUB

Efavirenz

INH

IND

INH

SUB

INH

IND

INH

IND

INH

SUB

IND

INH

Eletriptan

SUB

Eliglustat

SUB

Eltrombopag

INH

Elvitegravir

INH

SUB

Encainide

SUB

Enflurane

SUB

Enoxacin

INH

Enzalutamide

IND

Eplerenone

SUB

Ergotamine

SUB

Erlotinib

SUB

INH

SUB

INH

SUB

Erythromycin

INH

SUB

INH

SUB

INH

Escitalopram (S-citalopram)

SUB

INH

Esomeprazole

INH

SUB

Estradiol

SUB

IND

Ethanol

SUB

IND

SUB

IND

SUB

Ethinylestradiol

INH

SUB

INH

SUB

IND

Ethosuximide

SUB

Etoposide

SUB

IND

SUB

Etravirine

INH

SUB

INH

SUB

IND

SUB

Everolimus

SUB

Famotidine

SUB

Felbamate

INH

SUB

IND

SUB

Felodipine

SUB

INH

SUB

Fenofibrate

INH

Fentanyl

SUB

Fexofenadine

SUB

Fibrate

SUB

Finasteride

SUB

Flecainide

INH

SUB

Fluconazole

INH

Fluoroquinolones

INH

Fluorouracil (5-Fluorouracil)

SUB

IND

SUB

Fluoxetine

INH

SUB

INH

SUB

INH

SUB

INH

Nortriptyline

SUB

Fluvastatin

SUB

INH

SUB

Flurbiprofen

SUB

Fluvoxamine

INH

SUB

INH

SUB

INH

Fosamprenavir

INH

SUB

INH

SUB

Fosaprepitant

INH

Furafylline

INH

Furosemide

SUB

Galantamine

SUB

Ganciclovir

SUB

Gefitinib

INH

SUB

IND

INH

SUB

Gemfibrozil

INH

Gestodene

INH

SUB

Glibenclamide (Glyburide)

SUB

Gliclazide

SUB

Glimepiride

SUB

Glipizide

SUB

Glitazones

INH

Glucocorticoids

IND

Glyburide

SUB

Granisetron

SUB

Grapefruit

INH

Halofantrine

INH

Haloperidol

SUB

INH

SUB

INH

Halothane

SUB

Hexobarbital

SUB

Histamine H1 Receptor Antagonists

INH

Hydrocodone

PRO

SUB

Hydrocortisone

SUB

Hydroxyzine

INH

SUB

Hypericum (St. John's Wort)

IND

Ibrutinib

SUB

Ibuprofen

SUB

INH

Idelalisib

INH

Ifosfamide

SUB

IND

PRO

IND

Imatinib

SUB

INH

SUB

INH

SUB

INH

PRO

SUB

Imipramine

SUB

Indinavir

IND

SUB

IND

SUB

IND

SUB

Indomethacin

INH

SUB

IND

INH

Insulin

IND

Interferon

INH

Irbesartan

INH

SUB

INH

Irinotecan

SUB

Isoflurane

SUB

Isoniazid (isonicotinylhydrazide (INH))

INH

IND

INH

SUB

Isradipine

SUB

INH

Istradefylline

INH

Itraconazole

INH

SUB

INH

SUB

Ivacaftor

INH

SUB

Ketamine

SUB

Ketoconazole

INH

SUB

INH

SUB

Ketoprofen

SUB

Labetalol

SUB

INH

Lamotrigin

SUB

IND

Lansoprazole

IND

INH

SUB

INH

SUB

Lapatinib

INH

Ledipasvir

INH

SUB

Lercanidipine

SUB

Letrozole

SUB

Levomepromazine

INH

SUB

Lidocaine

SUB

Liquorice (licorice)

INH

Lomitapide

INH

SUB

Loperamide

SUB

Lopinavir

INH

SUB

INH

Lorazepam

SUB

Loratadine

SUB

Lorcaserin

INH

Lornoxicam

SUB

Losartan

INH

SUB

Lovastatin

INH

SUB

Lumefantrine

INH

SUB

Lurasidone

SUB

Maprotiline

SUB

Maraviroc

SUB

Medroxyprogesteron

SUB

INH

Mefenamic Acid

SUB

Mefloquine

SUB

Melatonin

SUB

Meloxicam

SUB

IND

Meperidine

SUB

INH

Meprobamate

IND

Mercaptopurin

SUB

Metamizole (Dipyrone)

IND

Metformin

SUB

Methadone

SUB

INH

SUB

INH

SUB

Methotrexate

SUB

IND

SUB

Methoxsalen (Xanthotoxin)

INH

Methoxyflurane

SUB

Methylcholanthrene

IND

Methylprednisolone

SUB

INH

SUB

Metoclopramide

INH

SUB

Metoprolol

SUB

INH

Metronidazole

SUB

INH

Mexiletine

INH

SUB

Mianserine

SUB

Mibefradil

INH

Miconazole

INH

Midazolam

SUB

IND

INH

Midodrine

INH

Mifepristone

INH

SUB

INH

Minaprine

SUB

Mirabegron

INH

Mirtazapine

SUB

Mitotane

IND

INH

Moclobemide

INH

SUB

INH

Modafinil

IND

INH

IND

SUB

Montelukast

INH

SUB

Morphine

SUB

Mycophenolate Mofetil

SUB

Nabumetone

SUB

Nafcillin

IND

Naloxegol

SUB

Naproxen

SUB

Nateglinide

INH

SUB

Nebivolol

SUB

Nefazodone

INH

IND

Nelfinavir

INH

SUB

INH

SUB

INH

SUB

Nevirapine

IND

SUB

IND

SUB

Nifedipine

INH

SUB

Nilotinib

INH

SUB

INH

SUB

Nilutamide

SUB

Nimodipine

SUB

INH

Nisoldipine

SUB

Nitrazepam

SUB

Nitrendipine

INH

SUB

INH

Norethindrone

IND

Norethisterone

SUB

Norfloxacin

INH

Norfluoxetine

INH

Olanzapine

SUB

Ombitasvir

INH

SUB

Omeprazole

IND

SUB

INH

SUB

INH

Pantoprazole

INH

SUB

INH

SUB

Ondansetron

SUB

Oral Contraceptives

INH

Oseltamivir

SUB

Oxazepam

SUB

Oxcarbazepine

INH

IND

SUB

Oxybutynine

SUB

Oxycodone

PRO

SUB

IND

Paclitaxel

SUB

IND

SUB

P-Aminohippuric Acid (Pah)

INH

Paritaprevir

INH

SUB

INH

SUB

Paroxetine

INH

SUB

INH

Pazopanib

SUB

Peginterferon Alpha-2A

INH

Penicillin G (Benzylpenicillin)

SUB

Perhexiline

SUB

Perphenazine

INH

SUB

INH

Phenacetin

SUB

Phenformin

SUB

Phenobarbital

IND

SUB

IND

SUB

IND

SUB

Phenprocoumone

SUB

Phenylbutazone

INH

Phenytoin

IND

SUB

IND

SUB

IND

INH

IND

SUB

Pimozide

SUB

Pioglitazone

SUB

IND

SUB

Piperine

INH

IND

Pirfenidone

SUB

Piroxicam

SUB

Pitavastatin

SUB

Posaconazole

INH

Prasugrel

INH

PRO

SUB

Pravastatin

SUB

Prednisolone

SUB

IND

SUB

Prednisone

IND

Primidone

IND

SUB

IND

Probenecid

INH

IND

INH

Progesterone

SUB

INH

Proguanil

SUB

Promethazine

INH

SUB

Propafenone

INH

SUB

INH

SUB

INH

Propofol

SUB

Propranolol

SUB

INH

SUB

IND

Quercetin

INH

IND

INH

Quetiapine

SUB

Quinidine

INH

SUB

INH

SUB

Quinine

SUB

INH

SUB

Rabeprazole

SUB

Ramelteon

SUB

Ramosetron

SUB

Ranitidine

SUB

INH

SUB

Ranolazine

INH

SUB

INH

Reboxetine

INH

SUB

INH

Repaglinide

SUB

Rifabutin

IND

SUB

IND

Rifampin (Rifampicin)

IND

SUB

INH

Rilpivirine

SUB

INH

Riluzole

SUB

Risperidone

INH

SUB

Ritonavir

IND

INH

IND

INH

IND

INH

SUB

INH

SUB

INH

SUB

INH

R-Mephobarbital

SUB

Romidepsin

SUB

Ropivacaine

SUB

Rosiglitazone

SUB

Rosuvastatin

SUB

Roxithromycine

INH

Rufinamide

IND

Salmeterol

SUB

Saquinavir

INH

SUB

INH

SUB

Saxagliptine

SUB

Secobarbital

IND

Selegiline

SUB

INH

SUB

INH

SUB

Sertraline

IND

SUB

INH

SUB

INH

SUB

INH

Sevoflurane

SUB

Sildenafil

SUB

IND

Silybum Marianum (milk thistle)

INH

Simeprevir

INH

SUB

INH

SUB

INH

Simvastatin

INH

SUB

INH

SUB

Sirolimus

SUB

INH

SUB

S-Mephenytoin

SUB

Sofosbuvir

SUB

Sorafenib

SUB

INH

SUB

INH

SUB

IND

Sparteine

SUB

Starfruit

INH

Suboxone

INH

Sufentanil

SUB

Sulfamethoxazole (SMZ, SMX)

INH

SUB

Sulfaphenazole (sulfafenazol)

INH

Sulfasalazine

SUB

Sunitinib

SUB

Suprofen

SUB

Tacrine

SUB

Tacrolimus

SUB

INH

SUB

INH

SUB

Tadalafil

SUB

IND

Tamoxifen

SUB

PRO

SUB

INH

Tamsulosine

SUB

Tasimelteon

SUB

Telaprevir

INH

SUB

INH

SUB

Telithromycin

INH

SUB

Temsirolimus

SUB

Teniposide

INH

SUB

Tenoxicam

SUB

Terbinafine

SUB

INH

SUB

Terfenadine

SUB

INH

SUB

Teriflunomide

IND

INH

Testosterone

SUB

Thc

SUB

Theophylline

SUB

Thioridazine

SUB

Thiotepa

INH

Thyroxin (Levothyroxine)

SUB

Ticagrelor

INH

SUB

Ticlopidine

INH

Timolol

SUB

Tipranavir

INH

SUB

INH

SUB

Tizanidine

SUB

Tofisopam

INH

Tolbutamide

SUB

Tolterodine

SUB

Tolvaptan

SUB

Topiramate

INH

IND

SUB

Torsemide (Torasemide)

SUB

Tramadol

SUB

PRO

SUB

Trazodone

SUB

IND

Triamterene

SUB

Triazolam

SUB

Trimethoprim

INH

Trimipramine

SUB

Tripelennamine

INH

Troglitazone

IND

Troleandomycin

INH

Tropisetron

SUB

Valproic acid (valproate)

INH

SUB

INH

SUB

INH

Vandetanib

INH

IND

Vardenafil

SUB

INH

Vegetables

IND

Vemurafenib

INH

SUB

Venlafaxine

SUB

Verapamil

INH

SUB

INH

SUB

INH

SUB

Vinblastine

INH

SUB

INH

SUB

Vincristine

SUB

IND

SUB

Voriconazole

INH

SUB

INH

SUB

INH

SUB

Warfarin

SUB

Zafirlukast

INH

SUB

Zaleplon

SUB

Zileuton

INH

SUB

Ziprasidone

SUB

Zolmitriptan

SUB

Zolpidem

SUB

Zopiclone

SUB

Zuclopenthixol

SUB

Tobacco smoke ( hydrocarbon, not nicotine)

IND

Lamivudine

SUB

Raltegravir

SUB

Vinorelbine

SUB

Dacarbazine

SUB

Doravirine

SUB

Acetylsalicylic acid

IND

SUB

Brivudin

INH

Sorivudin

INH

Candesartan

SUB

Digoxin

SUB

Azithromycin

SUB

INH

Spironolactone

INH

Hydrochlorothiazide

SUB

Abacavir

SUB

Fampridine

SUB

INH

SUB

Acetaminophen (Paracetamol) toxic dose

PRO

SUB

Elbasvir

SUB

Grazoprevir

SUB

Hydralazine

SUB

Nicotine

SUB

Flupentixol

SUB

INH

Melperon

INH

Raloxifene

INH

Fulvestrant

SUB

Cabergoline

SUB

Entacapone

INH

SUB

Lisuride

SUB

Pergolide

INH

SUB

Rasagiline

SUB

Biperiden

INH

Ropinirole

SUB

INH

SUB

Tolcapone

SUB

Clomethiazole

SUB

INH

SUB

INH

SUB

Hydroxychloroquine

INH

SUB

Asenapin

SUB

Cyproterone

SUB

Amphetamine

SUB

Dextroamphetamine

SUB

Elexacaftor

SUB

Tezacaftor

SUB

remdesivir

IND

SUB

IND

SUB

Entrectinib

SUB

Siponimod

SUB

Gilteritinib

SUB

Ozanimod

SUB

Ropeginterferon alpha-2b

INH

Darolutamid

SUB

Larotrectinib

SUB

Delafloxacine

SUB

Tucatinib

SUB

Alpelisib

SUB

Neratinib

SUB

Esketamin

SUB

Baloxavir

SUB

Lorlatinib

SUB

Upadacitinib

SUB

Apalutamid

SUB

Dacomitinib

SUB

Mercaptamine

SUB

Abemaciclib

SUB

Bictegravir

SUB

Emtricitabin

SUB

Natrium(4-phenylbutanoat)

IND

Edaravone

SUB

Pitolisant

SUB

Selpercatinib

SUB

Ertugliflozin

SUB

Stiripentol

SUB

INH

Brexpiprazol

IND

SUB

Cariprazine

SUB

Venetoclax

SUB

Letermovir

INH

SUB

Cabozantinib

SUB

INH

Velpatasvir

SUB

INH

Voxilaprevir

SUB

Isavuconazole

SUB

INH

Glecaprevir

SUB

INH

Baricitinib

SUB

Midostaurin

SUB

Lesinurad

SUB

Palbociclib

SUB

INH

Alectinib

SUB

Ivermectin

SUB

Loxapin

SUB

Migalastat

SUB

Brivaracetam

SUB

INH

Selexipag

SUB

Rizatriptane

SUB